Role of Copper in Iron Localization
نویسنده
چکیده
By JOSEPH R. GOODMAN AND PE r n R. DALLMAN C OPPER DEFICIENCY in the experimental animal results in a hypochromic microcytic anemia,”2 similar to that observed in certain conditions characterized by defective hemoglobin synthesis. Thus, a role for copper in the production of hemoglobin was proposed and actively investigated by Cartwright, Wintrobe, Lee and coworkers37 in copper-deficient swine. Their studies indicated that copper deficiency produces a defect in the release of iron to the circulation from the intestinal mucosa, reticuloendothelial system and the hepatocyte3-5; the pathways of porphyrin and heme synthesis in the
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